Dexamethasone-Loaded Thermosensitive Hydrogel Suppresses Inflammation and Pain in Collagen-Induced Arthritis Rats

PURPOSE: To overcome negative adverse effects and improve therapeutic index of dexamethasone (Dex) in rheumatoid arthritis (RA), we developed a novel sustained release formulation-intra-articular injectable dexamethasone-loaded thermosensitive hydrogel (DLTH) with chitosan-glycerin-borax as carrier...

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Dettagli Bibliografici
Pubblicato in:Drug Des Devel Ther
Autori principali: Wang, Qi-Shan, Xu, Bing-Xin, Fan, Kai-Jian, Li, Yun-Wu, Wu, Jing, Wang, Ting-Yu
Natura: Artigo
Lingua:Inglês
Pubblicazione: Dove 2020
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Original Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547127/
https://ncbi.nlm.nih.gov/pubmed/33116399
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S256850
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