Single-nucleus RNA-seq and FISH identify coordinated transcriptional activity in mammalian myofibers

Skeletal muscle fibers are large syncytia but it is currently unknown whether gene expression is coordinately regulated in their numerous nuclei. Here we show by snRNA-seq and snATAC-seq that slow, fast, myotendinous and neuromuscular junction myonuclei each have different transcriptional programs,...

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Vydáno v:Nat Commun
Hlavní autoři: Dos Santos, Matthieu, Backer, Stéphanie, Saintpierre, Benjamin, Izac, Brigitte, Andrieu, Muriel, Letourneur, Franck, Relaix, Frederic, Sotiropoulos, Athanassia, Maire, Pascal
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7547110/
https://ncbi.nlm.nih.gov/pubmed/33037211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18789-8
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