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Energy Landscape for the Membrane Fusion Pathway in Influenza A Hemagglutinin From Discrete Path Sampling

The conformational change associated with membrane fusion for Influenza A Hemagglutinin is investigated with a model based upon pre- and post-fusion structures of the HA2 component. We employ computational methods based on the potential energy landscape framework to obtain an initial path connecting...

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Veröffentlicht in:Front Chem
Hauptverfasser: Burke, David F., Mantell, Rosemary G., Pitt, Catherine E., Wales, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7546250/
https://ncbi.nlm.nih.gov/pubmed/33102445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2020.575195
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