Pharmacokinetics of Inter-Alpha Inhibitor Proteins and Effects on Hemostasis After Hypoxic-Ischemic Brain Injury in Neonatal Rats

BACKGROUND: Hypoxic-ischemic (HI) brain injury is a leading cause of long-term neurodevelopmental morbidities in neonates. Human plasma-derived Inter-Alpha Inhibitor Proteins (hIAIPs) are neuroprotective after HI brain injury in neonatal rats. The light chain (bikunin) of hIAIPs inhibits proteases i...

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Udgivet i:Curr Pharm Des
Main Authors: Chen, Xiaodi, Song, Dawei, Nakada, Sakura, Qiu, Joseph, Iwamoto, Karin, Chen, Ray H., Lim, Yow-Pin, Jusko, William J., Stonestreet, Barbara S.
Format: Artigo
Sprog:Inglês
Udgivet: 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7545274/
https://ncbi.nlm.nih.gov/pubmed/32316887
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/1381612826666200421123242
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