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Genetic aetiology of blood pressure relates to aortic stiffness with bi-directional causality: evidence from heritability, blood pressure polymorphisms, and Mendelian randomization

AIMS: Haemodynamic determinants of blood pressure (BP) include cardiac output (CO), systemic vascular resistance (SVR), and arterial stiffness. We investigated the heritability of these phenotypes, their association with BP-related single-nucleotide polymorphisms (SNPs), and the causal association b...

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Veröffentlicht in:Eur Heart J
Hauptverfasser: Cecelja, Marina, Keehn, Louise, Ye, Li, Spector, Tim D, Hughes, Alun D, Chowienczyk, Phil
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544538/
https://ncbi.nlm.nih.gov/pubmed/32357239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/eurheartj/ehaa238
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