Human ABCB1 with an ABCB11-like degenerate nucleotide binding site maintains transport activity by avoiding nucleotide occlusion

Several ABC exporters carry a degenerate nucleotide binding site (NBS) that is unable to hydrolyze ATP at a rate sufficient for sustaining transport activity. A hallmark of a degenerate NBS is the lack of the catalytic glutamate in the Walker B motif in the nucleotide binding domain (NBD). The multi...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Goda, Katalin, Dönmez-Cakil, Yaprak, Tarapcsák, Szabolcs, Szalóki, Gábor, Szöllősi, Dániel, Parveen, Zahida, Türk, Dóra, Szakács, Gergely, Chiba, Peter, Stockner, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7544095/
https://ncbi.nlm.nih.gov/pubmed/33031417
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1009016
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