Design and synthesis of thiadiazolo-carboxamide bridged β-carboline-indole hybrids: DNA intercalative topo-IIα inhibition with promising antiproliferative activity

The conjoining of salient pharmacophoric properties directing the development of prominent cytotoxic agents was executed by constructing thiadiazolo-carboxamide bridged β-carboline-indole hybrids. On the evaluation of in vitro cytotoxic potential, 12c exhibited prodigious cytotoxicity among the synt...

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Detalhes bibliográficos
Publicado no:Bioorg Chem
Main Authors: Tokala, Ramya, Sana, Sravani, Lakshmi, Uppu Jaya, Sankarana, Prasanthi, Sigalapalli, Dilep Kumar, Gadewal, Nikhil, Kode, Jyoti, Shankaraiah, Nagula
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Inc. 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7543778/
https://ncbi.nlm.nih.gov/pubmed/33091673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bioorg.2020.104357
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