Calreticulin promotes EMT in pancreatic cancer via mediating Ca(2+) dependent acute and chronic endoplasmic reticulum stress

BACKGROUND: Our previous study showed that calreticulin (CRT) promoted EGF-induced epithelial-mesenchymal transition (EMT) in pancreatic cancer (PC) via Integrin/EGFR-ERK/MAPK signaling. We next investigated the novel signal pathway and molecular mechanism involving the oncogenic role of CRT in PC....

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Veröffentlicht in:J Exp Clin Cancer Res
Hauptverfasser: Sheng, Weiwei, Wang, Guosen, Tang, Jingtong, Shi, Xiaoyang, Cao, Rongxian, Sun, Jian, Lin, Yi Heng, Jia, Chao, Chen, Chuanping, Zhou, Jianping, Dong, Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2020
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Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7542892/
https://ncbi.nlm.nih.gov/pubmed/33028359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-020-01702-y
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