Copy Number of an Integron-Encoded Antibiotic Resistance Locus Regulates a Virulence and Opacity Switch in Acinetobacter baumannii AB5075

We describe a novel genetic mechanism in which tandem amplification of a plasmid-borne integron regulates virulence, opacity variation, and global gene expression by altering levels of a putative small RNA (sRNA) in Acinetobacter baumannii AB5075. Copy number of this amplified locus correlated with...

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Bibliographic Details
Published in:mBio
Main Authors: Anderson, Sarah E., Chin, Chui Yoke, Weiss, David S., Rather, Philip N.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2020
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7542366/
https://ncbi.nlm.nih.gov/pubmed/33024041
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.02338-20
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