Receptor occupancy of dual glucagon-like peptide 1/glucagon receptor agonist SAR425899 in individuals with type 2 diabetes

Unimolecular dual agonists for the glucagon-like peptide 1 receptor (GLP1R) and glucagon receptor (GCGR) are emerging as a potential new class of important therapeutics in type 2 diabetes (T2D). Reliable and quantitative assessments of in vivo occupancy on each receptor would improve the understandi...

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Publicat a:Sci Rep
Autors principals: Eriksson, Olof, Haack, Torsten, Hijazi, Youssef, Teichert, Lenore, Tavernier, Veronique, Laitinen, Iina, Berglund, Jan Erik, Antoni, Gunnar, Velikyan, Irina, Johansson, Lars, Pierrou, Stefan, Wagner, Michael, Tillner, Joachim
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7542159/
https://ncbi.nlm.nih.gov/pubmed/33028880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73815-5
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