Astrocytes from cortex and striatum show differential responses to mitochondrial toxin and BDNF: implications for protection of striatal neurons expressing mutant huntingtin

BACKGROUND: Evidence shows significant heterogeneity in astrocyte gene expression and function. We previously demonstrated that brain-derived neurotrophic factor (BDNF) exerts protective effects on whole brain primary cultured rat astrocytes treated with 3-nitropropionic acid (3NP), a mitochondrial...

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Detalhes bibliográficos
Publicado no:J Neuroinflammation
Main Authors: Saba, Julieta, López Couselo, Federico, Turati, Juan, Carniglia, Lila, Durand, Daniela, de Laurentiis, Andrea, Lasaga, Mercedes, Caruso, Carla
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7542133/
https://ncbi.nlm.nih.gov/pubmed/33023623
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-020-01965-4
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