Increased canonical NF-kappaB signaling specifically in macrophages is sufficient to limit tumor progression in syngeneic murine models of ovarian cancer

BACKGROUND: New treatment options for ovarian cancer are urgently required. Tumor-associated macrophages (TAMs) are an attractive target for therapy; repolarizing TAMs from M2 (pro-tumor) to M1 (anti-tumor) phenotypes represents an important therapeutic goal. We have previously shown that upregulate...

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Publicado en:BMC Cancer
Main Authors: Hoover, Alyssa A., Hufnagel, Demetra H., Harris, Whitney, Bullock, Kennady, Glass, Evan B., Liu, Esther, Barham, Whitney, Crispens, Marta A., Khabele, Dineo, Giorgio, Todd D., Wilson, Andrew J., Yull, Fiona E.
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2020
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7542116/
https://ncbi.nlm.nih.gov/pubmed/33028251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-020-07450-8
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