Molecular evolutionary and structural analysis of human UCHL1 gene demonstrates the relevant role of intragenic epistasis in Parkinson’s disease and other neurological disorders

BACKGROUND: Parkinson’s disease (PD) is the second most common neurodegenerative disorder. PD associated human UCHL1 (Ubiquitin C-terminal hydrolase L1) gene belongs to the family of deubiquitinases and is known to be highly expressed in neurons (1–2% in soluble form). Several functions of UCHL1 hav...

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Vydáno v:BMC Evol Biol
Hlavní autoři: Nawaz, Muhammad Saqib, Asghar, Razia, Pervaiz, Nashaiman, Ali, Shahid, Hussain, Irfan, Xing, Peiqi, Bao, Yiming, Abbasi, Amir Ali
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2020
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7542113/
https://ncbi.nlm.nih.gov/pubmed/33028204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12862-020-01684-7
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