High Cell-Free DNA Levels in Cerebrospinal Fluid Predict Leptomeningeal Seeding of Hematologic Malignancy

BACKGROUND AND PURPOSE: The main difficulty when diagnosing leptomeningeal metastases (LMSs) is the low sensitivity of cytology. Cancer cells release cell-free DNA (cfDNA) during proliferation and apoptosis, and so we analyzed the cfDNA level as a biomarker for LMSs in hematologic malignancy. METHOD...

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Pubblicato in:J Clin Neurol
Autori principali: Kim, Eun Young, Lee, Soon-Tae, Kim, Young-Sook, Byun, Ja Min, Hong, Junshik, Shin, Dong-Yeop, Koh, Youngil, Kim, Inho
Natura: Artigo
Lingua:Inglês
Pubblicazione: Korean Neurological Association 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541998/
https://ncbi.nlm.nih.gov/pubmed/33029963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3988/jcn.2020.16.4.581
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