Antihistamine Drug Ebastine inhibits cancer growth by targeting Polycomb Group Protein EZH2

Enhancer of Zester Homolog 2 (EZH2), a histone lysine methyltransferase and the catalytic component of Polycomb Repressive Complex 2, has been extensively investigated as a chromatin regulator and a transcriptional suppressor by methylating H3 at lysine 27 (H3K27). EZH2 is upregulated or mutated in...

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Publicado no:Mol Cancer Ther
Main Authors: Li, Qiaqia, Liu, Kilia Y., Liu, Qipeng, Wang, Guangyu, Jiang, Weihua, Meng, Qingshu, Yi, Yang, Yang, Yongyong, Wang, Rui, Zhu, Sen, Li, Chao, Wu, Longxiang, Zhao, Dongyu, Yan, Lin, Zhang, Lili, Kim, Jung-Sun, Zu, Xiongbing, Kozielski, Anthony J., Qian, Wei, Chang, Jenny C., Patnaik, Akash, Chen, Kaifu, Cao, Qi
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541747/
https://ncbi.nlm.nih.gov/pubmed/32855270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-20-0250
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