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Transcription imparts architecture, function, and logic to enhancer units

Distal enhancers play pivotal roles in development and disease yet remain one of the least understood regulatory elements. We used massively parallel reporter assays to perform functional comparisons of two leading enhancer models and find that gene-distal transcription start sites (TSSs) are robust...

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Vydáno v:Nat Genet
Hlavní autoři: Tippens, Nathaniel D., Liang, Jin, King-Yung Leung, Alden, Wierbowski, Shayne D., Ozer, Abdullah, Booth, James G., Lis, John T., Yu, Haiyuan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541647/
https://ncbi.nlm.nih.gov/pubmed/32958950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0686-2
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