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Transcription imparts architecture, function, and logic to enhancer units

Distal enhancers play pivotal roles in development and disease yet remain one of the least understood regulatory elements. We used massively parallel reporter assays to perform functional comparisons of two leading enhancer models and find that gene-distal transcription start sites (TSSs) are robust...

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Detalhes bibliográficos
Publicado no:Nat Genet
Main Authors: Tippens, Nathaniel D., Liang, Jin, King-Yung Leung, Alden, Wierbowski, Shayne D., Ozer, Abdullah, Booth, James G., Lis, John T., Yu, Haiyuan
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7541647/
https://ncbi.nlm.nih.gov/pubmed/32958950
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41588-020-0686-2
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