Reactions in Tirapazamine Induced by the Attachment of Low‐Energy Electrons: Dissociation Versus Roaming of OH

Tirapazamine (TPZ) has been tested in clinical trials on radio‐chemotherapy due to its potential highly selective toxicity towards hypoxic tumor cells. It was suggested that either the hydroxyl radical or benzotriazinyl radical may form as bioactive radical after the initial reduction of TPZ in solu...

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Publicat a:Angew Chem Int Ed Engl
Autors principals: Arthur‐Baidoo, Eugene, Ameixa, João, Ziegler, Patrick, Ferreira da Silva, Filipe, Ončák, Milan, Denifl, Stephan
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2020
Matèries:
Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540495/
https://ncbi.nlm.nih.gov/pubmed/32543771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.202006675
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