SiRNA targeting PFK1 inhibits proliferation and migration and enhances radiosensitivity by suppressing glycolysis in colorectal cancer

Purpose: This study explored the effects of phosphofructokinase-1 (PFK1) on the radiosensitivity of colorectal cancer (CRC) in vivo and in vitro and the underlying mechanisms. Methods: Tissue samples from 48 patients with rectal cancer who had received neoadjuvant radiotherapy followed by surgery we...

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Udgivet i:Am J Transl Res
Main Authors: Tian, Rui-Fang, Li, Xiao-Fei, Xu, Cong, Wu, Hui, Liu, Lan, Wang, Li-Hui, He, Dong, Cao, Ke, Cao, Pei-Guo, Ma, John K, Huang, Cheng-Hui
Format: Artigo
Sprog:Inglês
Udgivet: e-Century Publishing Corporation 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540104/
https://ncbi.nlm.nih.gov/pubmed/33042398
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