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The discovery of dystrophin, the protein product of the Duchenne muscular dystrophy gene

Duchenne muscular dystrophy was a well‐established medical and genetic enigma by the 1970s. Why was the new mutation rate so high in all world populations? Why were affected boys doing well in early childhood, but then showed relentless progression of muscle wasting? What was wrong with the muscle?...

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Bibliographic Details
Published in:FEBS J
Main Author: Hoffman, Eric P.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2020
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7540009/
https://ncbi.nlm.nih.gov/pubmed/32608079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.15466
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