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The knockdown of the sepiapterin reductase gene suppresses the proliferation of breast cancer by inducing ROS-mediated apoptosis

Background: Sepiapterin reductase (SPR) is an important regulator of the biosynthesis of tetrahydrobiopterin (BH(4)), which has been shown to be a promoter of different kinds of tumors. This study aims to investigate the role of SPR in breast cancer and to explore its molecular mechanism. Methods: S...

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Vydáno v:Int J Clin Exp Pathol
Hlavní autoři: Zhang, Xiaojing, Chen, Yuzhong, Wang, Kangwei, Tang, Jingwei, Chen, Yansong, Jin, Gongsheng, Liu, Xianfu
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2020
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539867/
https://ncbi.nlm.nih.gov/pubmed/33042327
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