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Introduction of Somatic Mutation in MED12 Induces Wnt4/β-Catenin and Disrupts Autophagy in Human Uterine Myometrial Cell

Uterine fibroids (UFs) or leiomyoma are frequently associated with somatic mutations in the mediator complex subunit 12 (MED12) gene; however, the function of these mutations in human UF biology is yet to be determined. Herein, we determined the functional role of the most common MED12 somatic mutat...

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Detalhes bibliográficos
Publicado no:Reprod Sci
Main Authors: El Andaloussi, Abdeljabar, Al-Hendy, Ayman, Ismail, Nahed, Boyer, Thomas G., Halder, Sunil K.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539814/
https://ncbi.nlm.nih.gov/pubmed/32046450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s43032-019-00084-7
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