Trisomy 21 is Associated with Caspase-2 Upregulation in Cytotrophoblasts at the Maternal-Fetal Interface

Impaired placentation is implicated in poor perinatal outcomes associated with Trisomy 21. Earlier studies revealed abnormal cytotrophoblast differentiation along the invasive pathway as a contributing mechanism. To further elucidate the causes, we evaluated Caspase-2 expression at the protein level...

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Veröffentlicht in:Reprod Sci
Hauptverfasser: Leon-Martinez, Daisy, Robinson, Joshua F., Zdravkovic, Tamara, Genbacev, Olga, Gormley, Matthew, Mcmaster, Michael, Fisher, Susan J., Bianco, Katherine
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2020
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539800/
https://ncbi.nlm.nih.gov/pubmed/32046398
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s43032-019-00002-x
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