Uteroplacental Ischemia Is Associated with Increased PAPP-A2

Residence at high altitude (> 2500 m) has been associated with an increased frequency of preeclampsia. Pappalysin-2 (PAPP-A2) is an insulin-like growth factor binding protein-5 (IGFBP-5) protease that is elevated in preeclampsia, and up-regulated by hypoxia in placental explants. The relationship...

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Udgivet i:Reprod Sci
Main Authors: Lamale-Smith, Leah M., Gumina, Diane L., Kramer, Anita W., Browne, Vaughn A., Toledo-Jaldin, Lilian, Julian, Colleen G., Winn, Virginia D., Moore, Lorna G.
Format: Artigo
Sprog:Inglês
Udgivet: Springer International Publishing 2020
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Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539799/
https://ncbi.nlm.nih.gov/pubmed/31994005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s43032-019-00050-3
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