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CYP1A1 and Cnr nitroreductase bioactivated niclosamide in vitro
Niclosamide produces genotoxic effects, such as point mutations in Salmonella sp., sperm-head abnormalities in mice and clastogenic effects in human lymphocytes in vitro and in vivo. As cytochrome P450 could be involved in the bioactivation of niclosamide, we investigated which subfamily was involve...
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| Udgivet i: | Mutagenesis |
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| Main Authors: | , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Oxford University Press
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7539354/ https://ncbi.nlm.nih.gov/pubmed/23956140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/mutage/get043 |
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