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Disease‐specific phenotypes in iPSC‐derived neural stem cells with POLG mutations
Mutations in POLG disrupt mtDNA replication and cause devastating diseases often with neurological phenotypes. Defining disease mechanisms has been hampered by limited access to human tissues, particularly neurons. Using patient cells carrying POLG mutations, we generated iPSCs and then neural stem...
Αποθηκεύτηκε σε:
| Τόπος έκδοσης: | EMBO Mol Med |
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| Κύριοι συγγραφείς: | , , , , , , , , , , , , , , , , |
| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
John Wiley and Sons Inc.
2020
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7539330/ https://ncbi.nlm.nih.gov/pubmed/32840960 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.202012146 |
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