Glufosinate constrains synchronous and metachronous metastasis by promoting anti‐tumor macrophages

Glutamine synthetase (GS) generates glutamine from glutamate and controls the release of inflammatory mediators. In macrophages, GS activity, driven by IL10, associates to the acquisition of M2‐like functions. Conditional deletion of GS in macrophages inhibits metastasis by boosting the formation of...

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Detalhes bibliográficos
Publicado no:EMBO Mol Med
Main Authors: Menga, Alessio, Serra, Marina, Todisco, Simona, Riera‐Domingo, Carla, Ammarah, Ummi, Ehling, Manuel, Palmieri, Erika M, Di Noia, Maria Antonietta, Gissi, Rosanna, Favia, Maria, Pierri, Ciro L, Porporato, Paolo E, Castegna, Alessandra, Mazzone, Massimiliano
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7539200/
https://ncbi.nlm.nih.gov/pubmed/32885605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201911210
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