A Mechanism for Severity of Disease in Older Patients with COVID-19: The Nexus between Telomere Length and Lymphopenia

Background: Lymphopenia due to a plummeting T-cell count is a major feature of severe COVID-19. T-cell proliferation is telomere length (TL)-dependent and TL shortens with age. Older persons are disproportionally affected by severe COVID-19, and we hypothesized that those with short TL have less cap...

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Pubblicato in:medRxiv
Autori principali: Benetos, Athanase, Lai, Tsung-Po, Toupance, Simon, Labat, Carlos, Verhulst, Simon, Perret-Guillaume, Christine, Gautier, Sylvie, Ungeheuer, Marie-Noelle, Levy, Daniel, Susser, Ezra, Aviv, Abraham
Natura: Artigo
Lingua:Inglês
Pubblicazione: Cold Spring Harbor Laboratory 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536885/
https://ncbi.nlm.nih.gov/pubmed/33024983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/2020.10.01.20205393
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