c-Myc inactivation of p53 through the pan-cancer lncRNA MILIP drives cancer pathogenesis

The functions of the proto-oncoprotein c-Myc and the tumor suppressor p53 in controlling cell survival and proliferation are inextricably linked as “Yin and Yang” partners in normal cells to maintain tissue homeostasis: c-Myc induces the expression of ARF tumor suppressor (p14(ARF) in human and p19(...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Feng, Yu Chen, Liu, Xiao Ying, Teng, Liu, Ji, Qiang, Wu, Yongyan, Li, Jin Ming, Gao, Wei, Zhang, Yuan Yuan, La, Ting, Tabatabaee, Hessam, Yan, Xu Guang, Jamaluddin, M. Fairuz B., Zhang, Didi, Guo, Su Tang, Scott, Rodney J., Liu, Tao, Thorne, Rick F., Zhang, Xu Dong, Jin, Lei
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536215/
https://ncbi.nlm.nih.gov/pubmed/33020477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18735-8
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