Allosteric regulation of glutamate dehydrogenase deamination activity

Glutamate dehydrogenase (GDH) is a key enzyme interlinking carbon and nitrogen metabolism. Recent discoveries of the GDH specific role in breast cancer, hyperinsulinism/hyperammonemia (HI/HA) syndrome, and neurodegenerative diseases have reinvigorated interest on GDH regulation, which remains poorly...

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Udgivet i:Sci Rep
Main Authors: Bera, Soumen, Rashid, Mubasher, Medvinsky, Alexander B., Sun, Gui-Quan, Li, Bai-Lian, Acquisti, Claudia, Sljoka, Adnan, Chakraborty, Amit
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7536180/
https://ncbi.nlm.nih.gov/pubmed/33020580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73743-4
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