miR-26a mediates LC-PUFA biosynthesis by targeting the Lxrα–Srebp1 pathway in the marine teleost Siganus canaliculatus

MicroRNAs have been recently shown to be important regulators of lipid metabolism. However, the mechanisms of microRNA-mediated regulation of long-chain polyunsaturated fatty acid (LC-PUFA) biosynthesis in vertebrates remain largely unknown. Herein, we for the first time addressed the role of miR-26...

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Vydáno v:J Biol Chem
Hlavní autoři: Chen, Cuiying, Wang, Shuqi, Hu, Yu, Zhang, Mei, He, Xianda, You, Cuihong, Wen, Xiaobo, Monroig, Óscar, Tocher, Douglas R., Li, Yuanyou
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2020
Témata:
RNA
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7535907/
https://ncbi.nlm.nih.gov/pubmed/32759307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014858
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