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Structure-based validation can drastically under-estimate error rate in proteome-wide cross-linking mass spectrometry studies
Thorough quality assessment of novel interactions identified by proteome-wide cross-linking mass spectrometry (XL-MS) studies is critical. Almost all current XL-MS studies have validated cross-links against known 3D structures of representative protein complexes. Here we provide theoretical and expe...
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| Publicado en: | Nat Methods |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7534832/ https://ncbi.nlm.nih.gov/pubmed/32994567 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41592-020-0959-9 |
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