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Enzymatic degradation of RNA causes widespread protein aggregation in cell and tissue lysates
Most proteins in cell and tissue lysates are soluble. We show here that in lysate from human neurons, more than 1,300 proteins are maintained in a soluble and functional state by association with endogenous RNA, as degradation of RNA invariably leads to protein aggregation. The majority of these pro...
Guardado en:
| Publicado en: | EMBO Rep |
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| Autores principales: | , , , , , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2020
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7534620/ https://ncbi.nlm.nih.gov/pubmed/32945072 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embr.201949585 |
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