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Human Islets Contain a Beta Cell Type That Expresses Proinsulin But Not the Enzyme That Converts the Precursor to Insulin

In pancreatic beta cells, proinsulin (ProIN) undergoes folding in endoplasmic reticulum/Golgi system and is translocated to secretory vesicles for processing into insulin and C-peptide by the proprotein convertases (PC)1/3 and PC2, and carboxypeptidase E. Human beta cells show significant variation...

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Pubblicato in:J Histochem Cytochem
Autore principale: Teitelman, Gladys
Natura: Artigo
Lingua:Inglês
Pubblicazione: SAGE Publications 2020
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7534102/
https://ncbi.nlm.nih.gov/pubmed/32998631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1369/0022155420961361
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