4-Cl-edaravone and (E)-2-chloro-3-[(E)-phenyldiazenyl]-2-butenoic acid are the specific reaction products of edaravone with hypochlorite

3-Methyl-1-phenyl-2-pyrazolin-5-one (edaravone) is a synthetic one-electron antioxidant used as a drug for treatment against acute phase cerebral infarction in Japan. This drug also reacts with two-electron oxidants like peroxynitrite to give predominantly 4-nitrosoedaravone but no one-electron oxid...

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Dettagli Bibliografici
Pubblicato in:J Clin Biochem Nutr
Autori principali: Amekura, Sakiko, Nakajima, Misuzu, Watanabe, Mami, Saitoh, Makoto, Iida, Sayaka, Yamamoto, Yorihiro, Fujisawa, Akio
Natura: Artigo
Lingua:Inglês
Pubblicazione: the Society for Free Radical Research Japan 2020
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533859/
https://ncbi.nlm.nih.gov/pubmed/33041513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3164/jcbn.19-115
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