Antitumor Activity In Vivo and Vitro of New Chiral Derivatives of Baicalin and Induced Apoptosis via the PI3K/Akt Signaling Pathway

In this study, a pair of chiral baicalin (BA) derivatives were synthesized by combining BA with phenylalanine methyl ester based on molecular docking technology, namely BAD and BAL. Cell cytotoxicity trails showed that the cell growth inhibitory effects of both BAD and BAL were increased by 8- to 12...

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Bibliographic Details
Published in:Mol Ther Oncolytics
Main Authors: Hou, Yi, Pi, Chao, Feng, Xianhu, Wang, Yuanyuan, Fu, Shaozhi, Zhang, Xiaomei, Zhao, Ling, Wei, Yumeng
Format: Artigo
Language:Inglês
Published: American Society of Gene & Cell Therapy 2020
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Original Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533372/
https://ncbi.nlm.nih.gov/pubmed/33072864
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omto.2020.08.018
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