Genetic Testing for BCHE Variants Identifies Patients at Risk of Prolonged Neuromuscular Blockade in Response to Succinylcholine

BACKGROUND: Genetic variants in the BCHE (butyrylcholinesterase) gene are associated with reduced BChE enzyme activity and prolonged post-succinylcholine neuromuscular blockade, which can lead to postanesthetic apnea and respiratory depression. Testing for BChE deficiency is usually performed by bio...

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Bibliografiska uppgifter
I publikationen:Pharmgenomics Pers Med
Huvudupphovsmän: Zhu, Guang-dan, Dawson, Eric, Huskey, Angela, Gordon, Ronald J, Del Tredici, Andria L
Materialtyp: Artigo
Språk:Inglês
Publicerad: Dove 2020
Ämnen:
Original Research
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7533272/
https://ncbi.nlm.nih.gov/pubmed/33061533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/PGPM.S263741
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