Restoration of RNA helicase DDX5 suppresses hepatitis B virus (HBV) biosynthesis and Wnt signaling in HBV-related hepatocellular carcinoma

Rationale: RNA helicase DDX5 is downregulated during hepatitis B virus (HBV) replication, and poor prognosis HBV-related hepatocellular carcinoma (HCC). The aim of this study is to determine the mechanism and significance of DDX5 downregulation for HBV-driven HCC, and identify biologics to prevent D...

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Bibliographic Details
Published in:Theranostics
Main Authors: Mani, Saravana Kumar Kailasam, Yan, Bingyu, Cui, Zhibin, Sun, Jiazeng, Utturkar, Sagar, Foca, Adrien, Fares, Nadim, Durantel, David, Lanman, Nadia, Merle, Philippe, Kazemian, Majid, Andrisani, Ourania
Format: Artigo
Language:Inglês
Published: Ivyspring International Publisher 2020
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7532671/
https://ncbi.nlm.nih.gov/pubmed/33042264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/thno.49629
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