GABA uptake transporters support dopamine release in dorsal striatum with maladaptive downregulation in a parkinsonism model

Striatal dopamine (DA) is critical for action and learning. Recent data show that DA release is under tonic inhibition by striatal GABA. Ambient striatal GABA tone on striatal projection neurons can be determined by plasma membrane GABA uptake transporters (GATs) located on astrocytes and neurons. H...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Nat Commun
Hlavní autoři: Roberts, Bradley M., Doig, Natalie M., Brimblecombe, Katherine R., Lopes, Emanuel F., Siddorn, Ruth E., Threlfell, Sarah, Connor-Robson, Natalie, Bengoa-Vergniory, Nora, Pasternack, Nicholas, Wade-Martins, Richard, Magill, Peter J., Cragg, Stephanie J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7532441/
https://ncbi.nlm.nih.gov/pubmed/33009395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18247-5
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky