Essentiality of CTNNB1 in Malignant Transformation of Human Embryonic Stem Cells under Long-Term Suboptimal Conditions

Human embryonic stem cells (hESCs) gradually accumulate abnormal karyotypes during long-term suboptimal culture, which hinder their application in regenerative medicine. Previous studies demonstrated that the activation of CTNNB1 might be implicated in this process. Hence, the hESC line with stably...

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Detalhes bibliográficos
Publicado no:Stem Cells Int
Main Authors: Liu, Jie, Zeng, Sicong, Wang, Yang, Yu, Juan, Ouyang, Qi, Hu, Liang, Zhou, Di, Lin, Ge, Sun, Yi
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi 2020
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7532415/
https://ncbi.nlm.nih.gov/pubmed/33029148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2020/5823676
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