COP9 signalosome is an essential and druggable parasite target that regulates protein degradation

Understanding how the protozoan protein degradation pathway is regulated could uncover new parasite biology for drug discovery. We found the COP9 signalosome (CSN) conserved in multiple pathogens such as Leishmania, Trypanosoma, Toxoplasma, and used the severe diarrhea-causing Entamoeba histolytica...

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Dades bibliogràfiques
Publicat a:PLoS Pathog
Autors principals: Ghosh, Swagata, Farr, Laura, Singh, Aditya, Leaton, Laura-Ann, Padalia, Jay, Shirley, Debbie-Ann, Sullivan, David, Moonah, Shannon
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2020
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7531848/
https://ncbi.nlm.nih.gov/pubmed/32960936
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008952
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