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Discovery of gramicidin A analogues with altered activities by multidimensional screening of a one-bead-one-compound library
Gramicidin A (1) is a peptide antibiotic that disrupts the transmembrane ion concentration gradient by forming an ion channel in a lipid bilayer. Although long used clinically, it is limited to topical application because of its strong hemolytic activity and mammalian cytotoxicity, likely arising fr...
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| Publicado en: | Nat Commun |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Nature Publishing Group UK
2020
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7531004/ https://ncbi.nlm.nih.gov/pubmed/33004797 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-18711-2 |
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