Lactate production by Staphylococcus aureus biofilm inhibits HDAC11 to reprogram the host immune response during persistent infection

Staphylococcus aureus (S. aureus) is a leading cause of biofilm-associated prosthetic joint infection (PJI), resulting in significant disability and prolonged treatment. It is known that host leukocyte IL-10 production is required for S. aureus biofilm persistence in PJI. A S. aureus bursa aurealis...

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Detalhes bibliográficos
Publicado no:Nat Microbiol
Main Authors: Heim, Cortney E., Bosch, Megan E., Yamada, Kelsey J., Aldrich, Amy L., Chaudhari, Sujata S., Klinkebiel, David, Gries, Casey M., Alqarzaee, Abdulelah A., Li, Yixuan, Thomas, Vinai C., Seto, Edward, Karpf, Adam R., Kielian, Tammy
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529909/
https://ncbi.nlm.nih.gov/pubmed/32661313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41564-020-0756-3
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