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Pten deletion in Dmp1-expressing cells does not rescue the osteopenic effects of Wnt/β-catenin suppression.
Skeletal homeostasis is sensitive to perturbations in Wnt signaling. Beyond its role in bone, Wnt is a major target for pharmaceutical inhibition in a wide range of diseases, most notably cancers. Numerous clinical trials for Wnt-based candidates are currently underway, and Wnt inhibitors will likel...
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| Udgivet i: | J Cell Physiol |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7529875/ https://ncbi.nlm.nih.gov/pubmed/32529635 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.29792 |
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