CDKN2C-Null Leiomyosarcoma: A Novel, Genomically Distinct Class of TP53/RB1–Wild-Type Tumor With Frequent CIC Genomic Alterations and 1p/19q-Codeletion

PURPOSE: Leiomyosarcoma (LMS) harbors frequent mutations in TP53 and RB1 but few actionable genomic alterations. Here, we searched for recurrent actionable genomic alterations in LMS that occur in the absence of common untreatable oncogenic drivers. METHODS: Tissues from 276,645 unique advanced canc...

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Vydáno v:JCO Precis Oncol
Hlavní autoři: Williams, Erik A., Sharaf, Radwa, Decker, Brennan, Werth, Adrienne J., Toma, Helen, Montesion, Meagan, Sokol, Ethan S., Pavlick, Dean C., Shah, Nikunj, Williams, Kevin Jon, Venstrom, Jeffrey M., Alexander, Brian M., Ross, Jeffrey S., Albacker, Lee A., Lin, Douglas I., Ramkissoon, Shakti H., Elvin, Julia A.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Clinical Oncology 2020
Témata:
Original Reports
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529542/
https://ncbi.nlm.nih.gov/pubmed/33015533
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/PO.20.00040
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