PTH/PTHrP-SIK3 mediated pathway affects skeletogenesis through altered mTOR signaling

Several studies have suggested a role for the mammalian target of rapamycin (mTOR) in skeletal development and homeostasis, yet there is no evidence connecting mTOR with the key signaling pathways that regulate skeletogenesis. Herein we identified a PTH/PTHrP-SIK3-mTOR signaling cascade essential fo...

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Detalhes bibliográficos
Publicado no:Sci Transl Med
Main Authors: Csukasi, Fabiana, Duran, Ivan, Barad, Maya, Barta, Tomas, Gudernova, Iva, Trantirek, Lukas, Martin, Jorge, Kuo, Caroline Y., Woods, Jeremy, Lee, Hane, Cohn, Daniel H., Krejci, Pavel, Krakow, Deborah
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7529349/
https://ncbi.nlm.nih.gov/pubmed/30232230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aat9356
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