Evolution of resistance to fluoroquinolones by dengue virus serotype 4 provides insight into mechanism of action and consequences for viral fitness

Drugs against flaviviruses such as dengue (DENV) and Zika (ZIKV) virus are urgently needed. We previously demonstrated that three fluoroquinolones, ciprofloxacin, enoxacin, and difloxacin, suppress replication of six flaviviruses. To investigate the barrier to resistance and mechanism(s) of action o...

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Bibliografiske detaljer
Udgivet i:Virology
Main Authors: Scroggs, Stacey L.P., Gass, Jordan T., Chinnasamy, Ramesh, Widen, Steven G., Azar, Sasha R., Rossi, Shannan L., Arterburn, Jeffrey B., Vasilakis, Nikos, Hanley, Kathryn A.
Format: Artigo
Sprog:Inglês
Udgivet: The Authors. Published by Elsevier Inc. 2021
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528753/
https://ncbi.nlm.nih.gov/pubmed/33120225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2020.09.004
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