Astragaloside IV Derivative (LS-102) Alleviated Myocardial Ischemia Reperfusion Injury by Inhibiting Drp1(Ser616) Phosphorylation-Mediated Mitochondrial Fission

Our previous studies showed that Astragaloside IV derivative (LS-102) exhibited potent protective function against ischemia reperfusion (I/R) injury, but little is known about the mechanisms. Mitochondrial fission regulated by dynamin-related protein1 (Drp1) is a newly recognized determinant of mito...

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Udgivet i:Front Pharmacol
Main Authors: Chen, Li, Chen, Xiao-Yi, Wang, Qian-Long, Yang, Si-Jin, Zhou, Hua, Ding, Li-Sheng, Qing, Lin-Sen, Luo, Pei
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Pharmacology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528720/
https://ncbi.nlm.nih.gov/pubmed/33041784
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.01083
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