Break-induced replication promotes fragile telomere formation

TRF1 facilitates the replication of telomeric DNA in part by recruiting the BLM helicase, which can resolve G-quadruplexes on the lagging-strand template. Lagging-strand telomeres lacking TRF1 or BLM form fragile telomeres—structures that resemble common fragile sites (CFSs)—but how they are formed...

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Bibliografiske detaljer
Udgivet i:Genes Dev
Main Authors: Yang, Zhe, Takai, Kaori K., Lovejoy, Courtney A., de Lange, Titia
Format: Artigo
Sprog:Inglês
Udgivet: Cold Spring Harbor Laboratory Press 2020
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7528700/
https://ncbi.nlm.nih.gov/pubmed/32883681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.328575.119
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