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Break-induced replication promotes fragile telomere formation
TRF1 facilitates the replication of telomeric DNA in part by recruiting the BLM helicase, which can resolve G-quadruplexes on the lagging-strand template. Lagging-strand telomeres lacking TRF1 or BLM form fragile telomeres—structures that resemble common fragile sites (CFSs)—but how they are formed...
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| 出版年: | Genes Dev |
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| 主要な著者: | , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Cold Spring Harbor Laboratory Press
2020
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7528700/ https://ncbi.nlm.nih.gov/pubmed/32883681 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.328575.119 |
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