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Molecular basis for the bifunctional Uba4–Urm1 sulfur‐relay system in tRNA thiolation and ubiquitin‐like conjugation

The chemical modification of tRNA bases by sulfur is crucial to tune translation and to optimize protein synthesis. In eukaryotes, the ubiquitin‐related modifier 1 (Urm1) pathway is responsible for the synthesis of 2‐thiolated wobble uridine (U(34)). During the key step of the modification cascade,...

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Bibliografski detalji
Izdano u:EMBO J
Glavni autori: Pabis, Marta, Termathe, Martin, Ravichandran, Keerthiraju E, Kienast, Sandra D, Krutyhołowa, Rościsław, Sokołowski, Mikołaj, Jankowska, Urszula, Grudnik, Przemysław, Leidel, Sebastian A, Glatt, Sebastian
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527816/
https://ncbi.nlm.nih.gov/pubmed/32901956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020105087
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