Molecular basis for the bifunctional Uba4–Urm1 sulfur‐relay system in tRNA thiolation and ubiquitin‐like conjugation

The chemical modification of tRNA bases by sulfur is crucial to tune translation and to optimize protein synthesis. In eukaryotes, the ubiquitin‐related modifier 1 (Urm1) pathway is responsible for the synthesis of 2‐thiolated wobble uridine (U(34)). During the key step of the modification cascade,...

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Detalhes bibliográficos
Publicado no:EMBO J
Main Authors: Pabis, Marta, Termathe, Martin, Ravichandran, Keerthiraju E, Kienast, Sandra D, Krutyhołowa, Rościsław, Sokołowski, Mikołaj, Jankowska, Urszula, Grudnik, Przemysław, Leidel, Sebastian A, Glatt, Sebastian
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2020
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527816/
https://ncbi.nlm.nih.gov/pubmed/32901956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020105087
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