Molecular basis for the bifunctional Uba4–Urm1 sulfur‐relay system in tRNA thiolation and ubiquitin‐like conjugation

The chemical modification of tRNA bases by sulfur is crucial to tune translation and to optimize protein synthesis. In eukaryotes, the ubiquitin‐related modifier 1 (Urm1) pathway is responsible for the synthesis of 2‐thiolated wobble uridine (U(34)). During the key step of the modification cascade,...

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Détails bibliographiques
Publié dans:EMBO J
Auteurs principaux: Pabis, Marta, Termathe, Martin, Ravichandran, Keerthiraju E, Kienast, Sandra D, Krutyhołowa, Rościsław, Sokołowski, Mikołaj, Jankowska, Urszula, Grudnik, Przemysław, Leidel, Sebastian A, Glatt, Sebastian
Format: Artigo
Langue:Inglês
Publié: John Wiley and Sons Inc. 2020
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527816/
https://ncbi.nlm.nih.gov/pubmed/32901956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.2020105087
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