Modulation of the Promoter Activation Rate Dictates the Transcriptional Response to Graded BMP Signaling Levels in the Drosophila Embryo

Morphogen gradients specify cell fates during development, with a classic example being the bone morphogenetic protein (BMP) gradient’s conserved role in embryonic dorsal-ventral axis patterning. Here, we elucidate how the BMP gradient is interpreted in the Drosophila embryo by combining live imagin...

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Detalhes bibliográficos
Publicado no:Dev Cell
Main Authors: Hoppe, Caroline, Bowles, Jonathan R., Minchington, Thomas G., Sutcliffe, Catherine, Upadhyai, Priyanka, Rattray, Magnus, Ashe, Hilary L.
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Press 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7527239/
https://ncbi.nlm.nih.gov/pubmed/32758422
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2020.07.007
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